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http://www.webpagetest.org/result/150525_KD_Y3W/

Hi,
I've inherited a IIS 7.5 server running PHP 5.3.8 and MySQL. The first byte is always high, usually between 5-9s, even with a static page. I've been looking everywhere, but can't find anything. I'm more experienced with linux and apache, this microsoft environment is slowing me down. Any help would be welcome thanks.

I've search through many threads but so many are unique, I've tried some of the suggestions.

Thanks

It could be that the windows server is a little under powered or there are internal network problems. Try doing a trace route to the server to determine whether it is a problem on the server, or within the internet itself.

I think I'd start with MySQL tuning. Slow queries, check, optimize index tables, ensure database has memory assigned etc.
PHP opcode caching might not hurt along with a different method of page caching for the pages that are largely static.

Since you are familiar with Apache, perhaps migrate the site to that from IIS?