Another poor first byte time

[jarrod1937]

Yes, that large of a variance is probably due to multiple levels of caching at work. Standard database caching will cache the result set of recently run queries, causing even a slow query to return results in as little as 0.06 seconds, but then later after the cache is invalidated the same query may take 2 seconds. I'd seriously recommend doing a slow query log or running something like New Relic, to see what queries are causing you issues. The performance you're describing is textbook database overhead.